Disease relevance of peremin

• Compared to histamine, which causes constriction of airways and edema formation, the leukotrienes are three to four orders of magnitude more potent and the effects have longer duration [1].
• Blood specimens were obtained from each arm serially over a one-hour interval, and serum speciments were assessed for histamine, eosinophil chemotactic factor of anaphylaxis, and complement components [2].
• Topical glucocorticosteroids significantly reduced both the symptoms and the levels of histamine, TAME-esterase activity, and kinins in the early, late, and rechallenge allergic reactions [3].
• Autoantibodies against the high-affinity IgE receptor as a cause of histamine release in chronic urticaria [4].
• The severity of pruritus was scored weekly, and plasma histamine levels were measured at the beginning and end of each five-week period [5].

Psychiatry related information on peremin

• In a classical conditioning procedure in which an immunologic challenge was paired with the presentation of an odor, guinea pigs showed a plasma histamine increase when presented with the odor alone [6].
• We hypothesize that the activity of histamine cells is linked to the maintenance of waking, in contrast to activity in noradrenergic and serotonergic neurons, which is more tightly coupled to the maintenance of muscle tone in waking and its loss in REM sleep and cataplexy [7].
• We now report that, in contrast to these other monoaminergic "REM-off" cell groups, histamine neurons are active in cataplexy at a level similar to or greater than that in quiet waking [7].
• Here we provide several lines of evidence that orexin A induces wakefulness by means of the TMN and histamine H(1) receptor (H1R) [8].
• Effects of the histamine H(1) receptor blocker, pyrilamine, on spontaneous locomotor activity of rats with long-term portacaval anastomosis [9].

High impact information on peremin

• Most urticarias are induced by vasoactive mediators such as histamine released from mast cells [4].
• The histamine-releasing activity of the serum was abolished by passive sensitization of basophils with myeloma IgE, enhanced after dissociation of IgE by treatment with lactic acid, and induced by IgG fractions from the serum of all four patients [4].
• Heparin did not change the partial-thromboplastin time and did not modify the bronchoconstrictor response to histamine [10].
• Therapy with erythropoietin induced a decrease in plasma histamine concentrations in both groups of patients with uremia, and recurrences of pruritus after the discontinuation of erythropoietin were accompanied by increases in plasma histamine concentrations [5].
• Relief of pruritus and decreases in plasma histamine concentrations during erythropoietin therapy in patients with uremia [5].

Chemical compound and disease context of peremin

• In 17 patients with systemic mastocytosis, concentrations of tryptase in plasma were linearly related to those of histamine (P less than 0.01) [11].
• In an attempt to facilitate the diagnosis of mastocytosis, we measured the urinary excretion of histamine and two of its main metabolites (N tau-methylhistamine and N tau-methylimidazoleacetic acid) in eight adults with this disorder [12].
• The results reported here demonstrate that the histamine- and leukotriene-independent component of guinea pig anaphylaxis in vivo and in isolated lung parenchymal strips in vitro is mediated by PAF-acether [13].
• For example, the increase in vascular permeability, a fundamental phenomenon in trauma, anaphylaxis, or endotoxemia, might be mediated by PAF, LTs, PGs, peptides (e.g. kinins, substance P, CGRP) and amines (e.g. histamine in some species) [14].
• Cromolyn therapy in patients with bronchial asthma. Effect on inhalation challenge with allergen, histamine, and methacholine [15].

Biological context of peremin

• Direct skin testing, passive transfer of IgE antibodies, antigen-mediated histamine release from peripheral blood leukocytes and airway obstruction in response to inhalation challenge indicated IgE-mediated, Type I hypersensitivity [16].
• Histamine and nocturnal wheezing [17].
• To address this issue, we investigated whether histamine homeostasis is altered in poisoned people [18].
• In the rat basophilic leukaemia cell line RBL-2H3, which is a model system for the analysis of Fc epsilon RI-mediated signal transduction, surface engagement of Fc epsilon RI induces histamine release and the tyrosine phosphorylation of several distinct proteins [19].
• Histamine plays a part in induction of drinking by food intake [20].

Anatomical context of peremin

• We present a model for the control of immunoglobulin E (IgE)-mediated histamine release from human basophils [21].
• Letter: Reagin-mediated histamine release from human leukocytes by human IgG [22].
• The serum histamine concentration rose, with an augmentation of eosinophil and neutrophil chemotactic activities [23].
• Following an initial treatment with histamine, endothelial cells were unable to respond to histamine for 3 hr, after which the PGI2 biosynthetic response rapidly returned to normal by 4 1/2 hr [24].
• A positive clinical response was associated with an increase in the number of T-cell histamine H2 receptors to normal levels and with correction of the other immunologic abnormalities [25].

Associations of peremin with other chemical compounds

• Tryptase, a neutral protease selectively concentrated in the secretory granules of human mast cells (but not basophils), is released by mast cells together with histamine and serves as a marker of mast-cell activation [11].
• We measured 9 alpha, 11 beta-dihydroxy-15-oxo-2,3,18,19-tetranorprost-5-ene-1,20-dioic acid (PGD-M), the principal metabolite of prostaglandin D2, a mast-cell secretory product, to assess whether mast cells had been activated to release histamine [18].
• We studied the rate of nosocomial pneumonia among 130 patients given mechanical ventilation in an intensive care unit who were receiving as prophylaxis for stress ulcer either sucralfate (n = 61), which does not raise gastric pH, or conventional treatment with antacids, histamine type 2 (H2) blockers, or both (n = 69) [26].
• All six of the donors who had reactions had specific ethylene oxide-induced basophil histamine release (mean release [+/- SE], 34.2 +/- 5.6 percent), whereas none of four controls had specific histamine release in response to ethylene oxide (mean release, 5.7 +/- 1.2 percent; P less than 0.005) [27].
• Differential release of serotonin and histamine from mast cells [28].

Gene context of peremin

• Within minutes after stimulation with phorbol esters or histamine, human endothelial cells become adhesive for neutrophils; this interaction is inhibited by antibodies to GMP-140 [29].
• The synergism between PlGF and VEGF was specific, as PlGF deficiency impaired the response to VEGF, but not to bFGF or histamine [30].
• In contrast to IL-3, other cytokines (IL-5, granulocyte/macrophage colony-stimulating factor, and nerve growth factor) that also prime basophils for enhanced histamine and leukotriene C4 release did not promote IgER-induced IL-4 synthesis [31].
• IL 3 and GM-CSF possessed significant histamine-releasing activity in 8 of 10 and 12 of 14 subjects, respectively [32].
• These results suggest that mast cells may sustain chronic inflammatory processes by upregulating self-induction of IL-1 through histamine release [33].

Analytical, diagnostic and therapeutic context of peremin

• We compared this regimen with immunotherapy using insect venoms or placebo in groups of 20 patients matched for history and sensitivity, as judged by venom skin test, histamine release and IgE antibody to venom [34].
• We monitored their responses by means of symptom scores and measurements of the levels of histamine, tosyl-L-arginine methyl ester (TAME)-esterase activity, and kinins in nasal lavages [3].
• The percentage of T lymphocytes bearing histamine Type 2 receptors was lower in the atopic group than in the control group (P less than 0.001), but the percentage of cells with Type 1 receptors was the same in both groups [35].
• When the initial histamine treatment was carried out under mildly alkaline conditions, the complete return of activity was delayed to 8 hr after treatment [24].
• We undertook a 10-week placebo-controlled, double-blind, crossover study in a group of patients receiving hemodialysis who had severe pruritus, to investigate the effects of recombinant human erythropoietin on their pruritus and plasma histamine levels [5].

References